Recent Developments of Stetter Reaction A Brief Review

In this short review definition, mechanism, and recent developments of the Stetter reaction, in period last ten years from 2011 to 2021 are presented. This reaction comprises N-heterocyclic carbene (NHC)-catalyzed umpolung aldehydes followed by their capturing with activated carbon-carbon double bonds (Michael acceptors). work includes also progresses inter-molecular intra-molecular versions enantioselective transformations. Underscoring advances applications synthesis various heterocyclic systems total natural products have been introduced.